Anitdepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis


Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis by Jay C. Fournier, MA, Robert J. DeRubeis, PhD, Steven D. Hollon, PhD, Sona Dimidjian, PhD, Jay D. Amsterdam, MD, Richard C. Shelton, MD, Jan Fawcett, MD.
Journal of the American Medical Association (JAMA), volume 303, number 1, 47-53

1.0 hours of CE Credit                Cost = $10.00
The article can be downloaded at no cost by clicking on THIS LINK or pasting the following url in your browser:

Intermediate level
8-question true/false + multiple choice test

This study is a meta-analysis of research papers listed in PubMed, PsychINFO and the Cochrane Library databases.  The focus of the meta-analysis is on the difference between the medication effect and placebo effect for antidepressant drugs in depressions of varying severity.  

Course Objectives
After reading this paper the reader will be able to
1. Explain how the benefits of antidepressant medication appear to vary with the initial symptom severity of the person taking the medication.

2.   Explain at least one limitation of double blind studies of antidepressant drug trials.

Author affiliations:
University of Pennsylvania, Department of Psychology:   Dr. DeRubeis and Mr. Fournier
University of Pennsylvania, Department of Psychiatry: Dr. Amsterdam
Vanderbilt University, Department of Psychology: Dr. Hollon
Vanderbilt University, Department of Psychiatry: Dr. Shelton
University of Colorado, Boulder, Department of Psychlogy: Dr. Dimidjian
University of New Mexico School of Medicine, Department of Psychiatry: Dr. Fawcett

Disclosures of financial and other interests that constitute a potential conflict of interest are listed at the end of the paper.  The three MDs report financial ties to a number of pharmaceutical companies.